Simple nutrients bypass the requirement for HLH-30 in coupling lysosomal nutrient sensing to survival

Lysosomes are ubiquitous acidified organelles that degrade intracellular and extracellular material trafficked via multiple pathways. Lysosomes also sense cellular nutrient levels to regulate target of rapamycin (TOR) kinase, a signaling enzyme that drives growth and suppresses activity of the MiT/T...

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Bibliographic Details
Published in:PLoS Biol
Main Authors: Murphy, John T., Liu, Haiyan, Ma, Xiucui, Shaver, Alex, Egan, Brian M., Oh, Clara, Boyko, Alexander, Mazer, Travis, Ang, Samuel, Khopkar, Rohan, Javaheri, Ali, Kumar, Sandeep, Jiang, Xuntian, Ory, Daniel, Mani, Kartik, Matkovich, Scot J., Kornfeld, Kerry, Diwan, Abhinav
Format: Artigo
Language:Inglês
Published: Public Library of Science 2019
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Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6516633/
https://ncbi.nlm.nih.gov/pubmed/31086360
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pbio.3000245
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