Simple nutrients bypass the requirement for HLH-30 in coupling lysosomal nutrient sensing to survival

Lysosomes are ubiquitous acidified organelles that degrade intracellular and extracellular material trafficked via multiple pathways. Lysosomes also sense cellular nutrient levels to regulate target of rapamycin (TOR) kinase, a signaling enzyme that drives growth and suppresses activity of the MiT/T...

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Detalhes bibliográficos
Publicado no:PLoS Biol
Main Authors: Murphy, John T., Liu, Haiyan, Ma, Xiucui, Shaver, Alex, Egan, Brian M., Oh, Clara, Boyko, Alexander, Mazer, Travis, Ang, Samuel, Khopkar, Rohan, Javaheri, Ali, Kumar, Sandeep, Jiang, Xuntian, Ory, Daniel, Mani, Kartik, Matkovich, Scot J., Kornfeld, Kerry, Diwan, Abhinav
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2019
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6516633/
https://ncbi.nlm.nih.gov/pubmed/31086360
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pbio.3000245
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