Tau overexpression impairs neuronal endocytosis by decreasing the GTPase dynamin 1 through the miR‐132/MeCP2 pathway

Tauopathies are a class of neurodegenerative diseases that are characterized by pathological aggregation of tau protein, which is accompanied by synaptic disorders. However, the role of tau in endocytosis, a fundamental process in synaptic transmission, remains elusive. Here, we report that forced e...

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Vydáno v:Aging Cell
Hlavní autoři: Xie, Ao‐Ji, Hou, Tong‐Yao, Xiong, Wan, Huang, He‐Zhou, Zheng, Jie, Li, Ke, Man, Heng‐Ye, Hu, Ya‐Zhuo, Han, Zhi‐Tao, Zhang, Hong‐Hong, Wei, Na, Wang, Jian‐Zhi, Liu, Dan, Lu, Youming, Zhu, Ling‐Qiang
Médium: Artigo
Jazyk:Inglês
Vydáno: John Wiley and Sons Inc. 2019
Témata:
Short Take
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6516177/
https://ncbi.nlm.nih.gov/pubmed/30809933
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/acel.12929
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