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A Mouse Model for MeCP2 Duplication Syndrome: MeCP2 Overexpression Impairs Learning and Memory and Synaptic Transmission

Rett syndrome and MECP2 duplication syndrome are neurodevelopmental disorders that arise from loss-of-function and gain-of-function alterations in methyl-CpG binding protein 2 (MeCP2) expression, respectively. Although there have been studies examining MeCP2 loss of function in animal models, there...

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Detalhes bibliográficos
Main Authors: Na, Elisa S., Nelson, Erika D., Adachi, Megumi, Autry, Anita E., Mahgoub, Melissa A., Kavalali, Ege T., Monteggia, Lisa M.
Formato: Artigo
Idioma:Inglês
Publicado em: Society for Neuroscience 2012
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3835557/
https://ncbi.nlm.nih.gov/pubmed/22378884
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.6000-11.2012
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