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Elevated MeCP2 in Mice Causes Neurodegeneration Involving Tau Dysregulation and Excitotoxicity: Implications for the Understanding and Treatment of MeCP2 Triplication Syndrome

Expression of MeCP2 must be carefully regulated as a reduction or increase results in serious neurological disorders. We are studying transgenic mice in which the MeCP2 gene is expressed at about three times higher than the normal level. Male MeCP2- Tg mice, but not female mice, suffer motor and cog...

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Vydáno v:Mol Neurobiol
Hlavní autoři: Montgomery, Kristen R., Louis Sam Titus, A. S. C., Wang, Lulu, D’Mello, Santosh R.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2018
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6477919/
https://ncbi.nlm.nih.gov/pubmed/29637441
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s12035-018-1046-4
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