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Elevated MeCP2 in Mice Causes Neurodegeneration Involving Tau Dysregulation and Excitotoxicity: Implications for the Understanding and Treatment of MeCP2 Triplication Syndrome
Expression of MeCP2 must be carefully regulated as a reduction or increase results in serious neurological disorders. We are studying transgenic mice in which the MeCP2 gene is expressed at about three times higher than the normal level. Male MeCP2- Tg mice, but not female mice, suffer motor and cog...
Αποθηκεύτηκε σε:
| Τόπος έκδοσης: | Mol Neurobiol |
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| Κύριοι συγγραφείς: | , , , |
| Μορφή: | Artigo |
| Γλώσσα: | Inglês |
| Έκδοση: |
2018
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| Θέματα: | |
| Διαθέσιμο Online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6477919/ https://ncbi.nlm.nih.gov/pubmed/29637441 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s12035-018-1046-4 |
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