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Elevated MeCP2 in Mice Causes Neurodegeneration Involving Tau Dysregulation and Excitotoxicity: Implications for the Understanding and Treatment of MeCP2 Triplication Syndrome

Expression of MeCP2 must be carefully regulated as a reduction or increase results in serious neurological disorders. We are studying transgenic mice in which the MeCP2 gene is expressed at about three times higher than the normal level. Male MeCP2- Tg mice, but not female mice, suffer motor and cog...

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Detalhes bibliográficos
Publicado no:Mol Neurobiol
Main Authors: Montgomery, Kristen R., Louis Sam Titus, A. S. C., Wang, Lulu, D’Mello, Santosh R.
Formato: Artigo
Idioma:Inglês
Publicado em: 2018
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6477919/
https://ncbi.nlm.nih.gov/pubmed/29637441
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s12035-018-1046-4
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