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Elimination of senescent osteoclast progenitors has no effect on the age‐associated loss of bone mass in mice
Both an increase in osteoclast and a decrease in osteoblast numbers contribute to skeletal aging. Markers of cellular senescence, including expression of the cyclin inhibitor p16, increase with aging in several bone cell populations. The elimination of p16‐expressing cells in old mice, using the INK...
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| Publicado no: | Aging Cell |
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| Main Authors: | , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
John Wiley and Sons Inc.
2019
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6516158/ https://ncbi.nlm.nih.gov/pubmed/30773784 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/acel.12923 |
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