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Elimination of senescent osteoclast progenitors has no effect on the age‐associated loss of bone mass in mice

Both an increase in osteoclast and a decrease in osteoblast numbers contribute to skeletal aging. Markers of cellular senescence, including expression of the cyclin inhibitor p16, increase with aging in several bone cell populations. The elimination of p16‐expressing cells in old mice, using the INK...

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Bibliografski detalji
Izdano u:Aging Cell
Glavni autori: Kim, Ha‐Neui, Chang, Jianhui, Iyer, Srividhya, Han, Li, Campisi, Judith, Manolagas, Stavros C., Zhou, Daohong, Almeida, Maria
Format: Artigo
Jezik:Inglês
Izdano: John Wiley and Sons Inc. 2019
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6516158/
https://ncbi.nlm.nih.gov/pubmed/30773784
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/acel.12923
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