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A decrease in NAD(+) contributes to the loss of osteoprogenitors and bone mass with aging
Age-related osteoporosis is caused by a deficit in osteoblasts, the cells that secrete bone matrix. The number of osteoblast progenitors also declines with age associated with increased markers of cell senescence. The forkhead box O (FoxO) transcription factors attenuate Wnt/β-catenin signaling and...
Gardado en:
| Publicado en: | NPJ Aging Mech Dis |
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| Main Authors: | , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
Nature Publishing Group UK
2021
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC8016898/ https://ncbi.nlm.nih.gov/pubmed/33795658 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41514-021-00058-7 |
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