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Cxcl12 deletion in mesenchymal cells increases bone turnover and attenuates the loss of cortical bone caused by estrogen deficiency in mice

CXCL12 is abundantly expressed in reticular cells associated with the perivascular niches of the bone marrow (BM) and is indispensable for B-lymphopoiesis. Cxcl12 promotes osteoclastogenesis and has been implicated in pathologic bone resorption. We had shown earlier that estrogen receptor α deletion...

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Bibliografiske detaljer
Udgivet i:J Bone Miner Res
Main Authors: Ponte, Filipa, Kim, Ha-Neui, Iyer, Srividhya, Han, Li, Almeida, Maria, Manolagas, Stavros C.
Format: Artigo
Sprog:Inglês
Udgivet: 2020
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7725417/
https://ncbi.nlm.nih.gov/pubmed/32154948
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/jbmr.4002
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