Estrogens decrease osteoclast number by attenuating mitochondria oxidative phosphorylation and ATP production in early osteoclast precursors

Loss of estrogens at menopause is a major cause of osteoporosis and increased fracture risk. Estrogens protect against bone loss by decreasing osteoclast number through direct actions on cells of the myeloid lineage. Here, we investigated the molecular mechanism of this effect. We report that 17β-es...

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Publicado no:Sci Rep
Main Authors: Kim, Ha-Neui, Ponte, Filipa, Nookaew, Intawat, Ucer Ozgurel, Serra, Marques-Carvalho, Adriana, Iyer, Srividhya, Warren, Aaron, Aykin-Burns, Nukhet, Krager, Kimberly, Sardao, Vilma A., Han, Li, de Cabo, Rafael, Zhao, Haibo, Jilka, Robert L., Manolagas, Stavros C., Almeida, Maria
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2020
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7371870/
https://ncbi.nlm.nih.gov/pubmed/32686739
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-020-68890-7
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