Osteocyte RANKL is required for cortical bone loss with age and is induced by senescence

In aging mice, osteoclast number increases in cortical bone but declines in trabecular bone, suggesting that different mechanisms underlie age-associated bone loss in these 2 compartments. Osteocytes produce the osteoclastogenic cytokine RANKL, encoded by Tnfsf11. Tnfsf11 mRNA increases in cortical...

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Publicado en:JCI Insight
Main Authors: Kim, Ha-Neui, Xiong, Jinhu, MacLeod, Ryan S., Iyer, Srividhya, Fujiwara, Yuko, Cawley, Keisha M., Han, Li, He, Yonghan, Thostenson, Jeff D., Ferreira, Elisabeth, Jilka, Robert L., Zhou, Daohong, Almeida, Maria, O’Brien, Charles A.
Formato: Artigo
Idioma:Inglês
Publicado: American Society for Clinical Investigation 2020
Assuntos:
Research Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC7566701/
https://ncbi.nlm.nih.gov/pubmed/32870816
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/jci.insight.138815
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