Osteocyte RANKL is required for cortical bone loss with age and is induced by senescence

In aging mice, osteoclast number increases in cortical bone but declines in trabecular bone, suggesting that different mechanisms underlie age-associated bone loss in these 2 compartments. Osteocytes produce the osteoclastogenic cytokine RANKL, encoded by Tnfsf11. Tnfsf11 mRNA increases in cortical...

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Détails bibliographiques
Publié dans:JCI Insight
Auteurs principaux: Kim, Ha-Neui, Xiong, Jinhu, MacLeod, Ryan S., Iyer, Srividhya, Fujiwara, Yuko, Cawley, Keisha M., Han, Li, He, Yonghan, Thostenson, Jeff D., Ferreira, Elisabeth, Jilka, Robert L., Zhou, Daohong, Almeida, Maria, O’Brien, Charles A.
Format: Artigo
Langue:Inglês
Publié: American Society for Clinical Investigation 2020
Sujets:
Research Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC7566701/
https://ncbi.nlm.nih.gov/pubmed/32870816
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/jci.insight.138815
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