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Osteocyte RANKL is required for cortical bone loss with age and is induced by senescence
In aging mice, osteoclast number increases in cortical bone but declines in trabecular bone, suggesting that different mechanisms underlie age-associated bone loss in these 2 compartments. Osteocytes produce the osteoclastogenic cytokine RANKL, encoded by Tnfsf11. Tnfsf11 mRNA increases in cortical...
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| Publié dans: | JCI Insight |
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| Auteurs principaux: | , , , , , , , , , , , , , |
| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
American Society for Clinical Investigation
2020
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7566701/ https://ncbi.nlm.nih.gov/pubmed/32870816 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/jci.insight.138815 |
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