Soluble RANKL contributes to osteoclast formation in adult mice but not ovariectomy-induced bone loss

Receptor activator of NFkB ligand (RANKL) is a TNF-family cytokine required for osteoclast formation, as well as immune cell and mammary gland development. It is produced as a membrane-bound protein that can be shed to form a soluble protein. We created mice harboring a sheddase-resistant form of RA...

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Publicado en:Nat Commun
Main Authors: Xiong, Jinhu, Cawley, Keisha, Piemontese, Marilina, Fujiwara, Yuko, Zhao, Haibo, Goellner, Joseph J., O’Brien, Charles A.
Formato: Artigo
Idioma:Inglês
Publicado: Nature Publishing Group UK 2018
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC6060116/
https://ncbi.nlm.nih.gov/pubmed/30046091
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-018-05244-y
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