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Soluble RANKL contributes to osteoclast formation in adult mice but not ovariectomy-induced bone loss
Receptor activator of NFkB ligand (RANKL) is a TNF-family cytokine required for osteoclast formation, as well as immune cell and mammary gland development. It is produced as a membrane-bound protein that can be shed to form a soluble protein. We created mice harboring a sheddase-resistant form of RA...
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Publicado no: | Nat Commun |
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Main Authors: | , , , , , , |
Formato: | Artigo |
Idioma: | Inglês |
Publicado em: |
Nature Publishing Group UK
2018
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Assuntos: | |
Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6060116/ https://ncbi.nlm.nih.gov/pubmed/30046091 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-018-05244-y |
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