Osteocytes, not Osteoblasts or Lining Cells, are the Main Source of the RANKL Required for Osteoclast Formation in Remodeling Bone

The cytokine receptor activator of nuclear factor kappa B ligand (RANKL), encoded by the Tnfsf11 gene, is essential for osteoclastogenesis and previous studies have shown that deletion of the Tnfsf11 gene using a Dmp1-Cre transgene reduces osteoclast formation in cancellous bone by more than 70%. Ho...

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Detalhes bibliográficos
Publicado no:PLoS One
Main Authors: Xiong, Jinhu, Piemontese, Marilina, Onal, Melda, Campbell, Josh, Goellner, Joseph J., Dusevich, Vladimir, Bonewald, Lynda, Manolagas, Stavros C., O’Brien, Charles A.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2015
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4578942/
https://ncbi.nlm.nih.gov/pubmed/26393791
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0138189
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