Ranolazine Prevents Pressure Overload-Induced Cardiac Hypertrophy and Heart Failure by Restoring Aberrant Na(+) and Ca(2+) Handling

BACKGROUND: Cardiac hypertrophy and heart failure are characterized by increased late sodium current and abnormal Ca(2+) handling. Ranolazine, a selective inhibitor of the late sodium current, can reduce sodium accumulation and Ca(2+) overload. In this study, we investigated the effects of ranolazin...

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Pubblicato in:J Cell Physiol
Autori principali: Nie, Jiali, Duan, Quanlu, He, Mengying, Li, Xianqing, Wang, Bei, Zhou, Chi, Wu, Lujin, Wen, Zheng, Chen, Chen, Wang, Dao Wu, Alsina, Katherina M., Wehrens, Xander H.T., Wang, Dao Wen, Ni, Li
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2018
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6515545/
https://ncbi.nlm.nih.gov/pubmed/30488495
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/jcp.27791
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