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Ranolazine Prevents Pressure Overload-Induced Cardiac Hypertrophy and Heart Failure by Restoring Aberrant Na(+) and Ca(2+) Handling
BACKGROUND: Cardiac hypertrophy and heart failure are characterized by increased late sodium current and abnormal Ca(2+) handling. Ranolazine, a selective inhibitor of the late sodium current, can reduce sodium accumulation and Ca(2+) overload. In this study, we investigated the effects of ranolazin...
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| Publicat a: | J Cell Physiol |
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| Autors principals: | , , , , , , , , , , , , , |
| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
2018
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6515545/ https://ncbi.nlm.nih.gov/pubmed/30488495 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/jcp.27791 |
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