Junctophilin-2 Expression Silencing Causes Cardiocyte Hypertrophy and Abnormal Intracellular Calcium-Handling

BACKGROUND: Junctophilin-2 (JPH2), a protein expressed in the junctional membrane complex, is necessary for proper intracellular calcium (Ca(2+)) signaling in cardiac myocytes. Down-regulation of JPH2 expression in a model of cardiac hypertrophy was recently associated with defective coupling betwee...

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Main Authors: Landstrom, Andrew P., Kellen, Cherisse A., Dixit, Sayali S., van Oort, Ralph J., Garbino, Alejandro, Weisleder, Noah, Ma, Jianjie, Wehrens, Xander H.T., Ackerman, Michael J.
格式: Artigo
語言:Inglês
出版: 2011
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC3059380/
https://ncbi.nlm.nih.gov/pubmed/21216834
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/CIRCHEARTFAILURE.110.958694
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