Disrupted Junctional Membrane Complexes and Hyperactive Ryanodine Receptors Following Acute Junctophilin Knockdown in Mice

BACKGROUND: Excitation-contraction coupling in striated muscle requires proper communication of plasmalemmal voltage-activated Ca(2+) channels and Ca(2+) release channels on sarcoplasmic reticulum (SR) within junctional membrane complexes (JMCs). Whereas previous studies revealed a loss of JMCs and...

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Detalhes bibliográficos
Main Authors: van Oort, Ralph J., Garbino, Alejandro, Wang, Wei, Dixit, Sayali S., Landstrom, Andrew P., Gaur, Namit, De Almeida, Angela C., Skapura, Darlene G., Rudy, Yoram, Burns, Alan R., Ackerman, Michael J., Wehrens, Xander H.T.
Formato: Artigo
Idioma:Inglês
Publicado em: 2011
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3056402/
https://ncbi.nlm.nih.gov/pubmed/21339484
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/CIRCULATIONAHA.110.006437
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