Disrupted Junctional Membrane Complexes and Hyperactive Ryanodine Receptors Following Acute Junctophilin Knockdown in Mice

BACKGROUND: Excitation-contraction coupling in striated muscle requires proper communication of plasmalemmal voltage-activated Ca(2+) channels and Ca(2+) release channels on sarcoplasmic reticulum (SR) within junctional membrane complexes (JMCs). Whereas previous studies revealed a loss of JMCs and...

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Auteurs principaux: van Oort, Ralph J., Garbino, Alejandro, Wang, Wei, Dixit, Sayali S., Landstrom, Andrew P., Gaur, Namit, De Almeida, Angela C., Skapura, Darlene G., Rudy, Yoram, Burns, Alan R., Ackerman, Michael J., Wehrens, Xander H.T.
Format: Artigo
Langue:Inglês
Publié: 2011
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Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3056402/
https://ncbi.nlm.nih.gov/pubmed/21339484
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/CIRCULATIONAHA.110.006437
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