Targeting the neuronal calcium sensor DREAM with small-molecules for Huntington’s disease treatment

DREAM, a neuronal calcium sensor protein, has multiple cellular roles including the regulation of Ca(2+) and protein homeostasis. We recently showed that reduced DREAM expression or blockade of DREAM activity by repaglinide is neuroprotective in Huntington’s disease (HD). Here we used structure-base...

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Detalhes bibliográficos
Publicado no:Sci Rep
Main Authors: Lopez-Hurtado, Alejandro, Peraza, Diego A., Cercos, Pilar, Lagartera, Laura, Gonzalez, Paz, Dopazo, Xose M., Herranz, Rosario, Gonzalez, Teresa, Martin-Martinez, Mercedes, Mellström, Britt, Naranjo, Jose R., Valenzuela, Carmen, Gutierrez-Rodriguez, Marta
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2019
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6514012/
https://ncbi.nlm.nih.gov/pubmed/31086218
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-019-43677-7
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