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Targeting the neuronal calcium sensor DREAM with small-molecules for Huntington’s disease treatment
DREAM, a neuronal calcium sensor protein, has multiple cellular roles including the regulation of Ca(2+) and protein homeostasis. We recently showed that reduced DREAM expression or blockade of DREAM activity by repaglinide is neuroprotective in Huntington’s disease (HD). Here we used structure-base...
Αποθηκεύτηκε σε:
| Τόπος έκδοσης: | Sci Rep |
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| Κύριοι συγγραφείς: | , , , , , , , , , , , , |
| Μορφή: | Artigo |
| Γλώσσα: | Inglês |
| Έκδοση: |
Nature Publishing Group UK
2019
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| Θέματα: | |
| Διαθέσιμο Online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6514012/ https://ncbi.nlm.nih.gov/pubmed/31086218 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-019-43677-7 |
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