Activating transcription factor 6 derepression mediates neuroprotection in Huntington disease

Deregulated protein and Ca(2+) homeostasis underlie synaptic dysfunction and neurodegeneration in Huntington disease (HD); however, the factors that disrupt homeostasis are not fully understood. Here, we determined that expression of downstream regulatory element antagonist modulator (DREAM), a mult...

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Vydáno v:J Clin Invest
Hlavní autoři: Naranjo, José R., Zhang, Hongyu, Villar, Diego, González, Paz, Dopazo, Xose M., Morón-Oset, Javier, Higueras, Elena, Oliveros, Juan C., Arrabal, María D., Prieto, Angela, Cercós, Pilar, González, Teresa, De la Cruz, Alicia, Casado-Vela, Juan, Rábano, Alberto, Valenzuela, Carmen, Gutierrez-Rodriguez, Marta, Li, Jia-Yi, Mellström, Britt
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Clinical Investigation 2016
Témata:
Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4731176/
https://ncbi.nlm.nih.gov/pubmed/26752648
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI82670
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