The structural basis of translational control by eIF2 phosphorylation

Protein synthesis in eukaryotes is controlled by signals and stresses via a common pathway, called the integrated stress response (ISR). Phosphorylation of the translation initiation factor eIF2 alpha at a conserved serine residue mediates translational control at the ISR core. To provide insight in...

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Gepubliceerd in:Nat Commun
Hoofdauteurs: Adomavicius, Tomas, Guaita, Margherita, Zhou, Yu, Jennings, Martin D., Latif, Zakia, Roseman, Alan M., Pavitt, Graham D.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Nature Publishing Group UK 2019
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Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6513899/
https://ncbi.nlm.nih.gov/pubmed/31086188
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-019-10167-3
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