A16 SENSING OF A MICROBIAL METABOLITE BY FIBROBLASTS THROUGH THE PREGNANE X RECEPTOR RESTRAINS INFLAMMATION AND FIBROSIS IN MICE

BACKGROUND: Fibrosis is a serious and irreversible complication of Crohn’s disease (CD) that can lead to intestinal obstruction and has no effective treatment beyond surgical resection. The pathogenesis of fibrosis is incompletely understood however, it is thought to involve an aberrant repair respo...

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Bibliografiske detaljer
Udgivet i:J Can Assoc Gastroenterol
Main Authors: Flannigan, K L, Nieves, K, Alston, L, Mani, S, Hirota, S A
Format: Artigo
Sprog:Inglês
Udgivet: Oxford University Press 2019
Fag:
Oral Presentations
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6512679/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/jcag/gwz006.015
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