Lysosomal targeting of the ABC transporter TAPL is determined by membrane-localized charged residues

The human lysosomal polypeptide ABC transporter TAPL (ABC subfamily B member 9, ABCB9) transports 6–59-amino-acid-long polypeptides from the cytosol into lysosomes. The subcellular localization of TAPL depends solely on its N-terminal transmembrane domain, TMD0, which lacks conventional targeting se...

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Dettagli Bibliografici
Pubblicato in:J Biol Chem
Autori principali: Graab, Philipp, Bock, Christoph, Weiss, Konstantin, Hirth, Alexander, Koller, Nicole, Braner, Markus, Jung, Jennifer, Loehr, Frank, Tampé, Robert, Behrends, Christian, Abele, Rupert
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Biochemistry and Molecular Biology 2019
Soggetti:
Cell Biology
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6509505/
https://ncbi.nlm.nih.gov/pubmed/30877195
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA118.007071
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