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Peptide translocation by the lysosomal ABC transporter TAPL is regulated by coupling efficiency and activation energy

The lysosomal polypeptide transporter TAPL belongs to the superfamily of ATP-binding cassette transporters. TAPL forms a homodimeric transport complex, which translocates oligo- and polypeptides into the lumen of lysosomes driven by ATP hydrolysis. Although the structure and the function of ABC tran...

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Dades bibliogràfiques
Publicat a:Sci Rep
Autors principals: Bock, Christoph, Zollmann, Tina, Lindt, Katharina-Astrid, Tampé, Robert, Abele, Rupert
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group UK 2019
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6695453/
https://ncbi.nlm.nih.gov/pubmed/31417173
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-019-48343-6
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