Complementary Activity of ETV5, RBPJ, and TCF3 Drives Formative Transition from Naive Pluripotency

The gene regulatory network (GRN) of naive mouse embryonic stem cells (ESCs) must be reconfigured to enable lineage commitment. TCF3 sanctions rewiring by suppressing components of the ESC transcription factor circuitry. However, TCF3 depletion only delays and does not prevent transition to formativ...

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Publicado en:Cell Stem Cell
Main Authors: Kalkan, Tüzer, Bornelöv, Susanne, Mulas, Carla, Diamanti, Evangelia, Lohoff, Tim, Ralser, Meryem, Middelkamp, Sjors, Lombard, Patrick, Nichols, Jennifer, Smith, Austin
Formato: Artigo
Idioma:Inglês
Publicado: Cell Press 2019
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC6509416/
https://ncbi.nlm.nih.gov/pubmed/31031137
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.stem.2019.03.017
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