Complementary Activity of ETV5, RBPJ, and TCF3 Drives Formative Transition from Naive Pluripotency

The gene regulatory network (GRN) of naive mouse embryonic stem cells (ESCs) must be reconfigured to enable lineage commitment. TCF3 sanctions rewiring by suppressing components of the ESC transcription factor circuitry. However, TCF3 depletion only delays and does not prevent transition to formativ...

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Publicat a:Cell Stem Cell
Autors principals: Kalkan, Tüzer, Bornelöv, Susanne, Mulas, Carla, Diamanti, Evangelia, Lohoff, Tim, Ralser, Meryem, Middelkamp, Sjors, Lombard, Patrick, Nichols, Jennifer, Smith, Austin
Format: Artigo
Idioma:Inglês
Publicat: Cell Press 2019
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6509416/
https://ncbi.nlm.nih.gov/pubmed/31031137
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.stem.2019.03.017
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