Inhibition of glycogen synthase kinase-3 alleviates Tcf3 repression of the pluripotency network and increases embryonic stem cell resistance to differentiation

Self-renewal of rodent embryonic stem (ES) cells is enhanced by partial inhibition of glycogen synthase kinase-3 (Gsk3)1 2. This effect has variously been attributed to stimulation of Wnt signalling via β-catenin1, stabilisation of cMyc3, and global de-inhibition of anabolic processes4. Here we demo...

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Bibliografiske detaljer
Main Authors: Wray, Jason, Kalkan, Tüzer, Gomez-Lopez, Sandra, Eckardt, Dominik, Cook, Andrew, Kemler, Rolf, Smith, Austin
Format: Artigo
Sprog:Inglês
Udgivet: 2011
Fag:
Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3160487/
https://ncbi.nlm.nih.gov/pubmed/21685889
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncb2267
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