Glycogen Synthase Kinase 3 (GSK3) Inhibitor, SB-216763, Promotes Pluripotency in Mouse Embryonic Stem Cells

Canonical Wnt/β-catenin signaling has been suggested to promote self-renewal of pluripotent mouse and human embryonic stem cells. Here, we show that SB-216763, a glycogen synthase kinase-3 (GSK3) inhibitor, can maintain mouse embryonic stem cells (mESCs) in a pluripotent state in the absence of exog...

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Détails bibliographiques
Auteurs principaux: Kirby, Leslie A., Schott, Jason T., Noble, Brenda L., Mendez, Daniel C., Caseley, Paul S., Peterson, Sarah C., Routledge, Tyler J., Patel, Nilay V.
Format: Artigo
Langue:Inglês
Publié: Public Library of Science 2012
Sujets:
Research Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3383737/
https://ncbi.nlm.nih.gov/pubmed/22745733
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0039329
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