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Glycogen synthase kinase-3 (GSK3): regulation, actions, and diseases

Glycogen synthase kinase-3 (GSK3) may be the busiest kinase in most cells, with over 100 known substrates to deal with. How does GSK3 maintain control to selectively phosphorylate each substrate, and why was it evolutionarily favorable for GSK3 to assume such a large responsibility? GSK3 must be par...

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Publicat a:Pharmacol Ther
Autors principals: Beurel, Eleonore, Grieco, Steven F., Jope, Richard S.
Format: Artigo
Idioma:Inglês
Publicat: 2014
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4340754/
https://ncbi.nlm.nih.gov/pubmed/25435019
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.pharmthera.2014.11.016
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