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Glycogen synthase kinase-3 (GSK3): regulation, actions, and diseases

Glycogen synthase kinase-3 (GSK3) may be the busiest kinase in most cells, with over 100 known substrates to deal with. How does GSK3 maintain control to selectively phosphorylate each substrate, and why was it evolutionarily favorable for GSK3 to assume such a large responsibility? GSK3 must be par...

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Bibliografische gegevens
Gepubliceerd in:Pharmacol Ther
Hoofdauteurs: Beurel, Eleonore, Grieco, Steven F., Jope, Richard S.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2014
Onderwerpen:
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4340754/
https://ncbi.nlm.nih.gov/pubmed/25435019
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.pharmthera.2014.11.016
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