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Glycogen synthase kinase-3 (GSK3): regulation, actions, and diseases

Glycogen synthase kinase-3 (GSK3) may be the busiest kinase in most cells, with over 100 known substrates to deal with. How does GSK3 maintain control to selectively phosphorylate each substrate, and why was it evolutionarily favorable for GSK3 to assume such a large responsibility? GSK3 must be par...

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Podrobná bibliografie
Vydáno v:Pharmacol Ther
Hlavní autoři: Beurel, Eleonore, Grieco, Steven F., Jope, Richard S.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2014
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4340754/
https://ncbi.nlm.nih.gov/pubmed/25435019
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.pharmthera.2014.11.016
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