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Glycogen synthase kinase-3 (GSK3): regulation, actions, and diseases

Glycogen synthase kinase-3 (GSK3) may be the busiest kinase in most cells, with over 100 known substrates to deal with. How does GSK3 maintain control to selectively phosphorylate each substrate, and why was it evolutionarily favorable for GSK3 to assume such a large responsibility? GSK3 must be par...

詳細記述

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書誌詳細
出版年:Pharmacol Ther
主要な著者: Beurel, Eleonore, Grieco, Steven F., Jope, Richard S.
フォーマット: Artigo
言語:Inglês
出版事項: 2014
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC4340754/
https://ncbi.nlm.nih.gov/pubmed/25435019
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.pharmthera.2014.11.016
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