Long-Lasting Antidepressant Action of Ketamine, but Not Glycogen Synthase Kinase-3 Inhibitor SB216763, in the Chronic Mild Stress Model of Mice

BACKGROUND: Clinical studies demonstrate that the N-methyl-D-aspartate (NMDA) receptor antagonist, ketamine, induces rapid antidepressant effects in patients with refractive major depressive disorder and bipolar depression. This rapid onset of action makes ketamine a highly attractive drug for patie...

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Detalhes bibliográficos
Main Authors: Ma, Xian-Cang, Dang, Yong-Hui, Jia, Min, Ma, Rui, Wang, Fen, Wu, Jin, Gao, Cheng-Ge, Hashimoto, Kenji
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2013
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3563541/
https://ncbi.nlm.nih.gov/pubmed/23390559
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0056053
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