AXL/AKT axis mediated-resistance to BRAF inhibitor depends on PTEN status in melanoma

Multiple genetic mutations within melanoma not only cause lesion-specific responses to targeted therapy but also alter the molecular route of resistance to that therapy. Inactivation of PTEN occurs in up to 30% of melanomas, frequently with a concurrent activating BRAF mutation. PTEN loss regulates...

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Udgivet i:Oncogene
Main Authors: Zuo, Qiang, Liu, Jing, Huang, Liping, Qin, Yifei, Hawley, Teresa, Seo, Claire, Merlino, Glenn, Yu, Yanlin
Format: Artigo
Sprog:Inglês
Udgivet: 2018
Fag:
Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6508599/
https://ncbi.nlm.nih.gov/pubmed/29551771
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41388-018-0205-4
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