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AXL/AKT axis mediated-resistance to BRAF inhibitor depends on PTEN status in melanoma
Multiple genetic mutations within melanoma not only cause lesion-specific responses to targeted therapy but also alter the molecular route of resistance to that therapy. Inactivation of PTEN occurs in up to 30% of melanomas, frequently with a concurrent activating BRAF mutation. PTEN loss regulates...
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| Publicado no: | Oncogene |
|---|---|
| Main Authors: | , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2018
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6508599/ https://ncbi.nlm.nih.gov/pubmed/29551771 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41388-018-0205-4 |
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