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PHLPP1 mediates melanoma metastasis suppression through repressing AKT2 activation
PI3K/AKT pathway activation is thought to be a driving force in metastatic melanomas. Members of the pleckstrin homology (PH) domain leucine-rich repeat protein Ser/Thr specific phosphatase family (PHLPP1 and PHLPP2) can regulate AKT activation. By dephosphorylating specific serine residues in the h...
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| Publicat a: | Oncogene |
|---|---|
| Autors principals: | , , , , |
| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
2018
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6450546/ https://ncbi.nlm.nih.gov/pubmed/29391600 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41388-017-0061-7 |
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