Evidence That Ternary Complex (eIF2-GTP-tRNA(i)(Met))–Deficient Preinitiation Complexes Are Core Constituents of Mammalian Stress Granules

Environmental stress-induced phosphorylation of eIF2α inhibits protein translation by reducing the availability of eIF2-GTP-tRNA(i)Met, the ternary complex that joins initiator tRNA(Met) to the 43S preinitiation complex. The resulting untranslated mRNA is dynamically routed to discrete cytoplasmic f...

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Main Authors: Kedersha, Nancy, Chen, Samantha, Gilks, Natalie, Li, Wei, Miller, Ira J., Stahl, Joachim, Anderson, Paul
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Cell Biology 2002
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC65082/
https://ncbi.nlm.nih.gov/pubmed/11809833
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1091/mbc.01-05-0221
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