Initiation of Protein Synthesis by Hepatitis C Virus Is Refractory to Reduced eIF2 · GTP · Met-tRNA(i)(Met) Ternary Complex Availability

A cornerstone of the antiviral interferon response is phosphorylation of eukaryotic initiation factor (eIF)2α. This limits the availability of eIF2·GTP·Met-tRNA(i)(Met) ternary complexes, reduces formation of 43S preinitiation complexes, and blocks viral (and most cellular) mRNA translation. However...

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Main Authors: Robert, Francis, Kapp, Lee D., Khan, Shakila N., Acker, Michael G., Kolitz, Sarah, Kazemi, Shirin, Kaufman, Randal J., Merrick, William C., Koromilas, Antonis E., Lorsch, Jon R., Pelletier, Jerry
Format: Artigo
Jezik:Inglês
Izdano: The American Society for Cell Biology 2006
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Articles
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC1635388/
https://ncbi.nlm.nih.gov/pubmed/16928960
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1091/mbc.E06-06-0478
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