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High Content Imaging Assays for IL-6-Induced STAT3 Pathway Activation in Head and Neck Cancer Cell Lines

In the canonical STAT3 signaling pathway, IL-6 receptor engagement leads to the recruitment of latent STAT3 to the activated IL-6 complex and the associated Janus kinase (JAK) phosphorylates STAT3 at Y705. pSTAT3-Y705 dimers traffic into the nucleus and bind to specific DNA response elements in the...

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Publicat a:Methods Mol Biol
Autors principals: Johnston, Paul A., Sen, Malabika, Hua, Yun, Camarco, Daniel P., Shun, Tong Ying, Lazo, John S., Grandis, Jennifer R.
Format: Artigo
Idioma:Inglês
Publicat: 2018
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6507410/
https://ncbi.nlm.nih.gov/pubmed/29082496
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/978-1-4939-7357-6_14
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