Development and Validation of a High-Content Screening Assay to Identify Inhibitors of Cytoplasmic Dynein-Mediated Transport of Glucocorticoid Receptor to the Nucleus

Rapid ligand-induced trafficking of glucocorticoid nuclear hormone receptor (GR) from the cytoplasm to the nucleus is an extensively studied model for intracellular retrograde cargo transport employed in constructive morphogenesis and many other cellular functions. Unfortunately, potent and selectiv...

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Main Authors: Johnston, Paul A., Shinde, Sunita N., Hua, Yun, Shun, Tong Ying, Lazo, John S., Day, Billy W.
Formato: Artigo
Idioma:Inglês
Publicado em: Mary Ann Liebert, Inc. 2012
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Original Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3464420/
https://ncbi.nlm.nih.gov/pubmed/22830992
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1089/adt.2012.456
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