Characterization and Optimization of a Novel Protein–Protein Interaction Biosensor High-Content Screening Assay to Identify Disruptors of the Interactions Between p53 and hDM2

We present here the characterization and optimization of a novel imaging-based positional biosensor high-content screening (HCS) assay to identify disruptors of p53-hDM2 protein–protein interactions (PPIs). The chimeric proteins of the biosensor incorporated the N-terminal PPI domains of p53 and hDM...

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Main Authors: Dudgeon, Drew D., Shinde, Sunita N., Shun, Tong Ying, Lazo, John S., Strock, Christopher J., Giuliano, Kenneth A., Taylor, D. Lansing, Johnston, Patricia A., Johnston, Paul A.
Formato: Artigo
Idioma:Inglês
Publicado em: Mary Ann Liebert, Inc. 2010
Assuntos:
Original Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2929144/
https://ncbi.nlm.nih.gov/pubmed/20662736
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1089/adt.2010.0281
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