Development and Implementation of a High-Throughput High-Content Screening Assay to Identify Inhibitors of Androgen Receptor Nuclear Localization in Castration-Resistant Prostate Cancer Cells

Patients with castration-resistant prostate cancer (CRPC) can be treated with abiraterone, a potent inhibitor of androgen synthesis, or enzalutamide, a second-generation androgen receptor (AR) antagonist, both targeting AR signaling. However, most patients relapse after several months of therapy and...

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Bibliografische gegevens
Gepubliceerd in:Assay Drug Dev Technol
Hoofdauteurs: Johnston, Paul A., Nguyen, Minh M., Dar, Javid A., Ai, Junkui, Wang, Yujuan, Masoodi, Khalid Z., Shun, Tongying, Shinde, Sunita, Camarco, Daniel P., Hua, Yun, Huryn, Donna M., Wilson, Gabriela Mustata, Lazo, John S., Nelson, Joel B., Wipf, Peter, Wang, Zhou
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Mary Ann Liebert, Inc. 2016
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Original Articles
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4876501/
https://ncbi.nlm.nih.gov/pubmed/27187604
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1089/adt.2016.716
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