Inhibition of Androgen Receptor Function and Level in Castration-Resistant Prostate Cancer Cells by 2-[(isoxazol-4-ylmethyl)thio]-1-(4-phenylpiperazin-1-yl)ethanone

The androgen receptor (AR) plays a critical role in the development of castration-resistant prostate cancer (CRPC) as well as in the resistance to the second-generation AR antagonist enzalutamide and the selective inhibitor of cytochrome P450 17A1 (CYP17A1) abiraterone. Novel agents targeting AR may...

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Veröffentlicht in:Endocrinology
Hauptverfasser: Masoodi, Khalid Z., Eisermann, Kurtis, Yang, Zhenyu, Dar, Javid A., Pascal, Laura E., Nguyen, Minh, O’Malley, Katherine, Parrinello, Erica, Feturi, Firuz G., Kenefake, Alex N., Nelson, Joel B., Johnston, Paul A., Wipf, Peter, Wang, Zhou
Format: Artigo
Sprache:Inglês
Veröffentlicht: Endocrine Society 2017
Schlagworte:
Special Section: Targeting and Regulation of Hormone Signaling
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5659684/
https://ncbi.nlm.nih.gov/pubmed/28977599
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1210/en.2017-00408
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