Inhibition of Androgen Receptor Function and Level in Castration-Resistant Prostate Cancer Cells by 2-[(isoxazol-4-ylmethyl)thio]-1-(4-phenylpiperazin-1-yl)ethanone

The androgen receptor (AR) plays a critical role in the development of castration-resistant prostate cancer (CRPC) as well as in the resistance to the second-generation AR antagonist enzalutamide and the selective inhibitor of cytochrome P450 17A1 (CYP17A1) abiraterone. Novel agents targeting AR may...

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Pubblicato in:Endocrinology
Autori principali: Masoodi, Khalid Z., Eisermann, Kurtis, Yang, Zhenyu, Dar, Javid A., Pascal, Laura E., Nguyen, Minh, O’Malley, Katherine, Parrinello, Erica, Feturi, Firuz G., Kenefake, Alex N., Nelson, Joel B., Johnston, Paul A., Wipf, Peter, Wang, Zhou
Natura: Artigo
Lingua:Inglês
Pubblicazione: Endocrine Society 2017
Soggetti:
Special Section: Targeting and Regulation of Hormone Signaling
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5659684/
https://ncbi.nlm.nih.gov/pubmed/28977599
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1210/en.2017-00408
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