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Production of CRISPR/Cas9-Mediated Self-Cleaving Helper-Dependent Adenoviruses

Prolonged expression of CRISPR/Cas9 raises concerns about off-target cleavage, cytotoxicity, and immune responses. To address these issues, we have developed a system to produce helper-dependent adenoviruses that express CRISPR/Cas9 to direct cleavage of the vectors’ own genome after transduction of...

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Dettagli Bibliografici
Pubblicato in:Mol Ther Methods Clin Dev
Autori principali: Palmer, Donna J., Turner, Dustin L., Ng, Philip
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society of Gene & Cell Therapy 2019
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6506437/
https://ncbi.nlm.nih.gov/pubmed/31080846
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.omtm.2019.04.003
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