UHRF1 depletion and HDAC inhibition reactivate epigenetically silenced genes in colorectal cancer cells

BACKGROUND: Ubiquitin-like protein containing PHD and RING finger domains 1 (UHRF1) is a major regulator of epigenetic mechanisms and is overexpressed in various human malignancies. In this study, we examined the involvement of UHRF1 in aberrant DNA methylation and gene silencing in colorectal cance...

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Bibliografske podrobnosti
izdano v:Clin Epigenetics
Main Authors: Niinuma, Takeshi, Kitajima, Hiroshi, Kai, Masahiro, Yamamoto, Eiichiro, Yorozu, Akira, Ishiguro, Kazuya, Sasaki, Hajime, Sudo, Gota, Toyota, Mutsumi, Hatahira, Tomo, Maruyama, Reo, Tokino, Takashi, Nakase, Hiroshi, Sugai, Tamotsu, Suzuki, Hiromu
Format: Artigo
Jezik:Inglês
Izdano: BioMed Central 2019
Teme:
Research
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC6505222/
https://ncbi.nlm.nih.gov/pubmed/31064417
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13148-019-0668-3
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