UHRF1 depletion and HDAC inhibition reactivate epigenetically silenced genes in colorectal cancer cells

BACKGROUND: Ubiquitin-like protein containing PHD and RING finger domains 1 (UHRF1) is a major regulator of epigenetic mechanisms and is overexpressed in various human malignancies. In this study, we examined the involvement of UHRF1 in aberrant DNA methylation and gene silencing in colorectal cance...

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Veröffentlicht in:Clin Epigenetics
Hauptverfasser: Niinuma, Takeshi, Kitajima, Hiroshi, Kai, Masahiro, Yamamoto, Eiichiro, Yorozu, Akira, Ishiguro, Kazuya, Sasaki, Hajime, Sudo, Gota, Toyota, Mutsumi, Hatahira, Tomo, Maruyama, Reo, Tokino, Takashi, Nakase, Hiroshi, Sugai, Tamotsu, Suzuki, Hiromu
Format: Artigo
Sprache:Inglês
Veröffentlicht: BioMed Central 2019
Schlagworte:
Research
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6505222/
https://ncbi.nlm.nih.gov/pubmed/31064417
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13148-019-0668-3
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