UHRF1 depletion and HDAC inhibition reactivate epigenetically silenced genes in colorectal cancer cells

BACKGROUND: Ubiquitin-like protein containing PHD and RING finger domains 1 (UHRF1) is a major regulator of epigenetic mechanisms and is overexpressed in various human malignancies. In this study, we examined the involvement of UHRF1 in aberrant DNA methylation and gene silencing in colorectal cance...

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Publicado en:Clin Epigenetics
Main Authors: Niinuma, Takeshi, Kitajima, Hiroshi, Kai, Masahiro, Yamamoto, Eiichiro, Yorozu, Akira, Ishiguro, Kazuya, Sasaki, Hajime, Sudo, Gota, Toyota, Mutsumi, Hatahira, Tomo, Maruyama, Reo, Tokino, Takashi, Nakase, Hiroshi, Sugai, Tamotsu, Suzuki, Hiromu
Formato: Artigo
Idioma:Inglês
Publicado: BioMed Central 2019
Assuntos:
Research
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC6505222/
https://ncbi.nlm.nih.gov/pubmed/31064417
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13148-019-0668-3
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