UHRF1 depletion and HDAC inhibition reactivate epigenetically silenced genes in colorectal cancer cells

BACKGROUND: Ubiquitin-like protein containing PHD and RING finger domains 1 (UHRF1) is a major regulator of epigenetic mechanisms and is overexpressed in various human malignancies. In this study, we examined the involvement of UHRF1 in aberrant DNA methylation and gene silencing in colorectal cance...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Publicado no:Clin Epigenetics
Main Authors: Niinuma, Takeshi, Kitajima, Hiroshi, Kai, Masahiro, Yamamoto, Eiichiro, Yorozu, Akira, Ishiguro, Kazuya, Sasaki, Hajime, Sudo, Gota, Toyota, Mutsumi, Hatahira, Tomo, Maruyama, Reo, Tokino, Takashi, Nakase, Hiroshi, Sugai, Tamotsu, Suzuki, Hiromu
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2019
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6505222/
https://ncbi.nlm.nih.gov/pubmed/31064417
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13148-019-0668-3
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados