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UHRF1 depletion and HDAC inhibition reactivate epigenetically silenced genes in colorectal cancer cells
BACKGROUND: Ubiquitin-like protein containing PHD and RING finger domains 1 (UHRF1) is a major regulator of epigenetic mechanisms and is overexpressed in various human malignancies. In this study, we examined the involvement of UHRF1 in aberrant DNA methylation and gene silencing in colorectal cance...
Gardado en:
| Publicado en: | Clin Epigenetics |
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| Main Authors: | , , , , , , , , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
BioMed Central
2019
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6505222/ https://ncbi.nlm.nih.gov/pubmed/31064417 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13148-019-0668-3 |
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