Dual EZH2 and G9a inhibition suppresses multiple myeloma cell proliferation by regulating the interferon signal and IRF4-MYC axis

Epigenetic mechanisms such as histone modification play key roles in the pathogenesis of multiple myeloma (MM). We previously showed that EZH2, a histone H3 lysine 27 (H3K27) methyltransferase, and G9, a H3K9 methyltransferase, are potential therapeutic targets in MM. Moreover, recent studies sugges...

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Pubblicato in:Cell Death Discov
Autori principali: Ishiguro, Kazuya, Kitajima, Hiroshi, Niinuma, Takeshi, Maruyama, Reo, Nishiyama, Naotaka, Ohtani, Hitoshi, Sudo, Gota, Toyota, Mutsumi, Sasaki, Hajime, Yamamoto, Eiichiro, Kai, Masahiro, Nakase, Hiroshi, Suzuki, Hiromu
Natura: Artigo
Lingua:Inglês
Pubblicazione: Nature Publishing Group UK 2021
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7803977/
https://ncbi.nlm.nih.gov/pubmed/33436557
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41420-020-00400-0
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