DOT1L inhibition blocks multiple myeloma cell proliferation by suppressing IRF4-MYC signaling

Epigenetic alterations play an important role in the pathogenesis in multiple myeloma, but their biological and clinical relevance is not fully understood. Here, we show that DOT1L, which catalyzes methylation of histone H3 lysine 79, is required for myeloma cell survival. DOT1L expression levels we...

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Vydáno v:Haematologica
Hlavní autoři: Ishiguro, Kazuya, Kitajima, Hiroshi, Niinuma, Takeshi, Ishida, Tadao, Maruyama, Reo, Ikeda, Hiroshi, Hayashi, Toshiaki, Sasaki, Hajime, Wakasugi, Hideki, Nishiyama, Koyo, Shindo, Tetsuya, Yamamoto, Eiichiro, Kai, Masahiro, Sasaki, Yasushi, Tokino, Takashi, Nakase, Hiroshi, Suzuki, Hiromu
Médium: Artigo
Jazyk:Inglês
Vydáno: Ferrata Storti Foundation 2019
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6312027/
https://ncbi.nlm.nih.gov/pubmed/30171029
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3324/haematol.2018.191262
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