DOT1L inhibition blocks multiple myeloma cell proliferation by suppressing IRF4-MYC signaling

Epigenetic alterations play an important role in the pathogenesis in multiple myeloma, but their biological and clinical relevance is not fully understood. Here, we show that DOT1L, which catalyzes methylation of histone H3 lysine 79, is required for myeloma cell survival. DOT1L expression levels we...

Popoln opis

Shranjeno v:
Bibliografske podrobnosti
izdano v:Haematologica
Main Authors: Ishiguro, Kazuya, Kitajima, Hiroshi, Niinuma, Takeshi, Ishida, Tadao, Maruyama, Reo, Ikeda, Hiroshi, Hayashi, Toshiaki, Sasaki, Hajime, Wakasugi, Hideki, Nishiyama, Koyo, Shindo, Tetsuya, Yamamoto, Eiichiro, Kai, Masahiro, Sasaki, Yasushi, Tokino, Takashi, Nakase, Hiroshi, Suzuki, Hiromu
Format: Artigo
Jezik:Inglês
Izdano: Ferrata Storti Foundation 2019
Teme:
Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC6312027/
https://ncbi.nlm.nih.gov/pubmed/30171029
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3324/haematol.2018.191262
Oznake: Označite
Brez oznak, prvi označite!

Podobne knjige/članki