DOT1L inhibition blocks multiple myeloma cell proliferation by suppressing IRF4-MYC signaling

Epigenetic alterations play an important role in the pathogenesis in multiple myeloma, but their biological and clinical relevance is not fully understood. Here, we show that DOT1L, which catalyzes methylation of histone H3 lysine 79, is required for myeloma cell survival. DOT1L expression levels we...

Ful tanımlama

Kaydedildi:
Detaylı Bibliyografya
Yayımlandı:Haematologica
Asıl Yazarlar: Ishiguro, Kazuya, Kitajima, Hiroshi, Niinuma, Takeshi, Ishida, Tadao, Maruyama, Reo, Ikeda, Hiroshi, Hayashi, Toshiaki, Sasaki, Hajime, Wakasugi, Hideki, Nishiyama, Koyo, Shindo, Tetsuya, Yamamoto, Eiichiro, Kai, Masahiro, Sasaki, Yasushi, Tokino, Takashi, Nakase, Hiroshi, Suzuki, Hiromu
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Ferrata Storti Foundation 2019
Konular:
Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC6312027/
https://ncbi.nlm.nih.gov/pubmed/30171029
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3324/haematol.2018.191262
Etiketler: Etiketle
Etiket eklenmemiş, İlk siz ekleyin!

Benzer Materyaller