TET1 Depletion Induces Aberrant CpG Methylation in Colorectal Cancer Cells

Aberrant DNA methylation is commonly observed in colorectal cancer (CRC), but the underlying mechanism is not fully understood. 5-hydroxymethylcytosine levels and TET1 expression are both reduced in CRC, while epigenetic silencing of TET1 is reportedly associated with the CpG island methylator pheno...

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Udgivet i:PLoS One
Main Authors: Kai, Masahiro, Niinuma, Takeshi, Kitajima, Hiroshi, Yamamoto, Eiichiro, Harada, Taku, Aoki, Hironori, Maruyama, Reo, Toyota, Mutsumi, Sasaki, Yasushi, Sugai, Tamotsu, Tokino, Takashi, Nakase, Hiroshi, Suzuki, Hiromu
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2016
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5158030/
https://ncbi.nlm.nih.gov/pubmed/27977763
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0168281
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