Epigenetic silencing of miR-340-5p in multiple myeloma: mechanisms and prognostic impact

BACKGROUND: miR-340-5p, localized to 5q35, is a tumor suppressor miRNA implicated in multiple cancers. As a CpG island is present at the putative promoter region of its host gene, RNF130, we hypothesized that the intronic miR-340-5p is a tumor suppressor miRNA epigenetically silenced by promoter DNA...

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Bibliographic Details
Published in:Clin Epigenetics
Main Authors: Li, Zhenhai, Wong, Kwan Yeung, Calin, George A., Chng, Wee-Joo, Chan, Godfrey Chi-fung, Chim, Chor Sang
Format: Artigo
Language:Inglês
Published: BioMed Central 2019
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Research
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6505104/
https://ncbi.nlm.nih.gov/pubmed/31064412
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13148-019-0669-2
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